L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
ammonia in chloroform T=0°C; 0.5 h;
参考文献
Tolmacheva; Igosheva; Grishko; Zhukova; Gerasimova
Russian Journal of Bioorganic Chemistry, 2010 , vol. 36, # 3 p. 377 - 382
反应条件
1.1: 91 percent / aq. Na2CO3 / toluene / 1 h / 5 - 10 °C
2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
3.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C
4.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C
View Scheme
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070
反应条件
1: 93 percent / bis<<4-(2,2-dimethyl-1,3-dioxolyl)methyl>carbodiimide, Et3N / dimethylformamide / 24 h / Ambient temperature
2: 97 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
反应条件
triethylamine in dichloromethane
Ambient temperature;
参考文献
Ukaji, Yutaka; Miyamoto, Masanori; Mikuni, Miho; Takeuchi, Susumu; Inomata, Katsuhiko
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 3 p. 735 - 742
反应条件
4-methyl-morpholine; 4-(N,N-dimethlyamino)pyridine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine; triethylamine in dichloromethane
T=35°C; 0.1 h; microwave irradiation;
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Porcheddu, Andrea; Salaris, Margherita
Synlett, 2004 , # 14 p. 2570 - 2572
反应条件
in toluene
4.5 h; Heating / reflux;
参考文献
LA JOLLA PHARMACEUTICAL COMPANY
Patent: WO2005/82343 A2, 2005 ;
Location in patent: Page/Page column 96 ;
反应条件
triethylamine in chloroform
T=0 - 10°C; 3 h;
参考文献
Karim, A.; Mortreux, A.; Petit, F.; Buono, G.; Pfeiffer, G.; Siv, C.
Journal of Organometallic Chemistry, 1986 , vol. 317, p. 93 - 104
反应条件
triethylamine in dichloromethane
12 h; Ambient temperature;
参考文献
Duczek; Deutsch; Vieth; Niclas
Synthesis, 1996 , # 1 p. 37 - 38
参考文献
Giesemann, Gerhard; Ugi, Ivar
Synthesis, 1983 , # 10 p. 788 - 789
反应条件
toluene-4-sulfonic acid
参考文献
Sun, Dequn; Zhang, Lingzi; Wang, Jin
Asian Journal of Chemistry, 2012 , vol. 24, # 1 p. 319 - 322
