L-苯丙氨酸甲酯盐酸盐 合成路线 （共 169 条）
反应条件
4-methyl-morpholine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
16 h;
参考文献
Carney, Daniel W.; Truong, Jonathan V.; Sello, Jason K.
反应条件
1.1: 91 percent / aq. Na2CO3 / toluene / 1 h / 5 - 10 °C
2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
3.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C
4.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C
5.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C
6.1: H2 / Pd/C / methanol / 4.5 h / 5 °C
7.1: aq. Na2CO3 / CH2Cl2 / 1 h / 20 °C
8.1: K2CO3 / methanol / 6 h / 20 °C
9.1: 7.55 g / ethanol / 3 h / Heating
10.1: aq. K2CO3 / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke
反应条件
2-hydroxymethyl-pyridine; zinc trifluoromethanesulfonate; triethylamine in methanol
T=20°C; 0.5 h;
参考文献
Felten, Albert E.; Zhu, Gangguo; Aron, Zachary D.
反应条件
1: 78 percent / NaBH4 / aq. ethanol / 1.) room temperature, 4 h, 2.) reflux, 6 h, 3.) room temperature, overnight
2: KH
View Scheme
参考文献
Meyers,A.I.; Williams,D.R.; Erickson,G.W.
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=0 - 20°C; 16 h; Inert atmosphere;
参考文献
Coste, Alexis; Toumi, Mathieu; Wright, Karen; Razafimahaleo, Vanessa; Couty, Francois; Marrot, Jerome; Evano, Gwilherm
反应条件
(enzymatic coupling);
参考文献
Isowa,Y.; Ichikawa,T.
反应条件
1: diisopropylethylamine / CH2Cl2; dimethylformamide; ethyl acetate / 4 h / Ambient temperature
2: 80 percent / phosphate buffer / 2-methyl-propan-2-ol / 35 °C / alcalase
View Scheme
参考文献
Chen; Hsiao; Chang; Wang
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反应条件
857637-92-4 4-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1.1: 70 percent / triethylamine / tetrahydrofuran; hexane / 2 h / 0 °C
2.1: t-BuLi / diethyl ether; hexane / -78 - -60 °C
2.2: diethyl ether; hexane / -78 - 20 °C
3.1: 99 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
4.1: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
反应条件
1.1: sodium tetrahydroborate / water / 16 h / 0 - 5 °C
1.2: pH 5
1.3: 3 h / |Reflux
2.1: triethylamine / dichloromethane / |Reflux
3.1: tetrabutylammomium bromide; potassium carbonate; p-toluenesulfonyl chloride / dichloromethane / 0 - 25 °C
View Scheme
参考文献
MYLAN LABORATORIES LTD.; RAMA, Shankar; VADALI, Lakshmana Rao; KONDA, Ramesh Babu; JALDU, Ravikanth; VEMAVARAPU, Govardhana Phani Sharma; PALLA, Vijay Kumar; YERVA, Eswara Reddy
反应条件
triethylamine in acetonitrile
T=20°C; 6 h;
参考文献
Leleu, Stephane; Penhoat, Mael; Bouet, Alexis; Dupas, Georges; Papamicael, Cyril; Marsais, Francis; Levacher, Vincent
