L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane
参考文献
Donkor; Sanders, M. Lee
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 19 p. 2647 - 2649
反应条件
Sephadex G-50; triethylamine; bromelain in ethyl acetate
T=37°C; 7 h;
参考文献
Tai, Dar-Fu; Fu, Shu-Lin
Journal of the Chinese Chemical Society, 2003 , vol. 50, # 1 p. 179 - 183
反应条件
TEA in 1,4-dioxane
T=10°C; 0.5 h;
参考文献
Hartrodt; Neubert; Jakubke; Balaspiri; Telegdy
Pharmazie, 1982 , vol. 37, # 6 p. 403 - 407
反应条件
1: 85 percent / Et3N, hydroxybenzotriazole (HOBt) / CH2Cl2 / 16 h
2: 45percent HBr/CH3COOH / 0.5 h
3: Et3N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h
4: 87 percent / 4 N aq. NaOH / methanol / 1 h / 0 °C
5: 1.) Et3N, 2.) hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0.5 h, 2.) DMF, RT, 16 h
View Scheme
参考文献
Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania
Polish Journal of Chemistry, 1980 , vol. 54, # 9 p. 1707 - 1712
反应条件
1: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5
2: 98 percent / 2.5 N NaOH / methanol / 25 °C
3: 95 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5
View Scheme
参考文献
Pfeiffer; Chambers; Hilbert; Woodward; Ackerman
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 325 - 341
反应条件
1: 92 percent / Et3N, DCC / CH2Cl2 / 0 - 20 °C
2: 100 percent / HCl / ethyl acetate / 2 h / 0 °C
View Scheme
参考文献
Bonnamour, Julien; Metro, Thomas-Xavier; Martinez, Jean; Lamaty, Frederic
Green Chemistry, 2013 , vol. 15, # 5 p. 1116 - 1120
反应条件
1: 1.) Et3N / 1.) CHCl3, 2.) CHCl3, 10 min, then 4 h, reflux
2: 57 percent / NaOH / H2O / 5 h / Ambient temperature
View Scheme
参考文献
Buntain, Ian G.; Suckling, Colin J.; Wood, Hamish C. S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3175 - 3182
反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.25 h / 0 °C
1.2: 24 h / 20 °C
2.1: sodium hydroxide / methanol / 10 h
3.1: trifluoroacetic acid / 2 h / 20 °C
View Scheme
参考文献
Adhikari, Bimalendu; Kraatz, Heinz-Bernhard
Chemical Communications, 2014 , vol. 50, # 42 p. 5551 - 5553
反应条件
1: 93 percent / DCC, Et3N / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) 25 deg C, 23 h
2: 1.) H2, 2.) Et3N / 1.) 10percent Pd/C / 1.) CH3OH, 1 atm, 25 deg C, 3 h, 2.) 25 deg C, 16 h
3: 84 percent / CH2Cl2 / 50 h / 25 °C
4: 63 percent / BH3*THF / tetrahydrofuran / 2 h / Heating
5: 25 percent / TsOH / CH2Cl2; H2O / 95 h / 25 °C
View Scheme
参考文献
Williams, Robert M.; Brunner, Eduard J.; Sabol, Mark R.
Synthesis, 1988 , # 12 p. 963 - 966
反应条件
1: 66 percent / DEPBT; TEA / dimethylformamide / 20 °C
2: NaOH
View Scheme
参考文献
Xie; Tian; Ye
Synthetic Communications, 2000 , vol. 30, # 23 p. 4233 - 4240
