L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
1: 78 percent 2: 1) 10percent aq.NaOH, Bu4NHSO4 / 1) CH2Cl2, r.t., 1 h, 2) CH2Cl2, r.t., 4 h 3: 93 percent / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
O'Donnell; Cook; Rusterholz
Synthesis, 1991 , # 11 p. 989 - 993
反应条件
1: DCC, Et3N / CH2Cl2 2: CH2Cl2 View Scheme
参考文献
Papanastassiou,Z.B. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 701 - 706
反应条件
1: 80 percent / DIEA / CH2Cl2 / 5 h / 20 °C 2: NaBH4 / tetrahydrofuran; H2O / 5 h / 20 °C View Scheme
参考文献
Mu, Qi Ming; Xue, Cui Hua; Zhang, Qing Hua; Chen, Shu Hua
Synthetic Communications, 2003 , vol. 33, # 17 p. 3055 - 3061
反应条件
1: 98 percent / Py 2: 92 percent / H2N-NH2 / methanol / 48 h / 20 °C View Scheme
参考文献
Diaz, David D.; Finn
Chemistry - A European Journal, 2004 , vol. 10, # 1 p. 303 - 309
反应条件
1: 37 percent / KI, K2CO3 / dimethylformamide / 1 h / 100 °C 2: 40 percent / K2CO3 / acetonitrile / 12 h 3: 10 percent / CsF / dimethylformamide / Ambient temperature View Scheme
参考文献
Zhang, Chen; Ito, Hiroto; Maeda, Yasuhiro; Shirai, Naohiro; Ikeda, Shin-Ichi; Sato, Yoshiro
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 581 - 586
参考文献
Diaz, David D.; Finn
Chemistry - A European Journal, 2004 , vol. 10, # 1 p. 303 - 309
反应条件
triethylamine in chloroform 0.5 h; Ambient temperature;
参考文献
Hlavacek, Jan; Fric, Ivo; Budesinsky, Milos; Blaha, Karel
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 11A p. 2473 - 2494
反应条件
1: (L)-phenylalanine methyl ester hydrochloride With p-nitrophenyl carbonate Merrifield resin; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Solid phase reaction; 6 h; 2: acetyl-bromide With triethylamine; zinc dibromide in dichloromethane T=20°C; Solid phase reaction;
参考文献
Li; Lin; Yo
Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6619 - 6622
反应条件
4-methyl-morpholine in methanol T=20°C; 24 h;
参考文献
Hioki, Kazuhito; Kameyama, Satomi; Tani, Shohei; Kunishima, Munetaka
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 5 p. 825 - 828
反应条件
1: 1.) n-Bu4N(1+)*OH(1-), 2.) triethylamine / 1.) methanol, 2.) DMF 2: 90 percent / 2.5N HCl / ethyl acetate 3: 1.) n-Bu4N(1+)*OH(1-), 2.) Et3N / 1.) MeOH, 2.) DMF 4: 90 percent / 1N NaOH, H2O / methanol 5: 1.) n-Bu4N(1+)*OH(1-), 2.) Et3N / 1.) MeOH, 2.) DMF 6: H2 / Pd/C / acetic acid 7: 2.5N HCl / dioxane View Scheme
参考文献
Watanabe, Yutaka; Morito, Naoya; Kamekawa, Ken-ichi; Mukaiyama, Teruaki
Chemistry Letters, 1981 , p. 65 - 68
