L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
in water; acetonitrile T=37°C; pH=4 - 10; Further byproducts given. Title compound not separated from byproducts;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 52, # 23 p. 7126 - 7131
反应条件
1: benzaldehyde; 4-formyl-benzoic acid; pyrrole With acetic acid in nitrobenzene T=120°C; Condensation; 1 h; 2: (L)-phenylalanine methyl ester hydrochloride With 4-(N,N-dimethlyamino)pyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; Condensation; 18 h;
参考文献
Photochemistry and Photobiology, , vol. 69, # 5 p. 517 - 528
反应条件
1: triethylamine / tetrahydrofuran / 24 h / 20 °C 2: ethanol; water / 24 h / 20 °C View Scheme
参考文献
Da Costa, Cristiane F.; Pinheiro, Alessandra C.; De Almeida, Mauro V.; Lourenco, Maria C.S.; De Souza, Marcus V.N.
Chemical Biology and Drug Design, 2012 , vol. 79, # 2 p. 216 - 222
反应条件
1: triethylamine / dichloromethane / 0 - 25 °C 2: lithium borohydride / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Chemistry - An Asian Journal, , vol. 6, # 1 p. 189 - 197
反应条件
in diethyl ether T=0°C; Inert atmosphere;
参考文献
Shen, Tianhua; Li, Junqi; Cui, Funa; Zhou, Xiaocong; Chen, Xiaoli; Song, Qingbao
Journal of the Chemical Society of Pakistan, 2013 , vol. 35, # 5 p. 1354 - 1358
反应条件
in diethyl ether T=20°C;
参考文献
Zhou, Zhongqiang; Guo, Yajing
Synthetic Communications, 2008 , vol. 38, # 5 p. 684 - 696
反应条件
1: bromobenzene With magnesium in diethyl ether 2: (L)-phenylalanine methyl ester hydrochloride in diethyl ether T=0 - 20°C;
参考文献
Da, Chao-Shan; Han, Zhi-jian; Ni, Ming; Yang, Fan; Liu, Da-Xue; Zhou, Yi-Feng; Wang, Rui
Tetrahedron Asymmetry, 2003 , vol. 14, # 6 p. 659 - 665
反应条件
1.1: sodium hydroxide / diethyl ether; water 2.1: diethyl ether / 18 h / 60 °C 2.2: Cooling with ice View Scheme
参考文献
Campbell, Craig D.; Concellon, Carmen; Smith, Andrew D.
Tetrahedron Asymmetry, 2011 , vol. 22, # 7 p. 797 - 811
反应条件
1.1: 1-propanephosphonic acid cyclic anhydride; 4-methyl-morpholine / dichloromethane; acetonitrile / 5 h / -15 - 25 °C 2.1: triethylamine; water; lithium bromide / acetonitrile / 5.17 h / 0 - 20 °C 2.2: 0 - 2 °C / pH 3 - 4 3.1: 1-propanephosphonic acid cyclic anhydride; 4-methyl-morpholine / dichloromethane; acetonitrile / 1.5 h / -15 - 25 °C View Scheme
参考文献
SYNTHON BV; CASTULIK, Jakub; ZABADAL, Miroslav
Patent: WO2012/48745 A1, 2012 ;
反应条件
hydrogenchloride; sodium hydroxide 1.) water, 0-5 deg C, pH 8.5-9.5, 2.) MeOH, water, 0 deg C, pH 4.5-5; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Vinick, Fredic J.; Jung, Stanley
Tetrahedron Letters, 1982 , vol. 23, # 13 p. 1315 - 1318
