L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
1: 91 percent / triethylamine 2: 98 percent / sodium borohydride, lithium chloride / tetrahydrofuran; ethanol 3: 100 percent / H2 / Rh-Al2O3 / acetic acid; methanol / 5 h / 3040 Torr / Ambient temperature 4: 78 percent / sulfur trioxide pyridine, triethylamine, dimethylsulfoxide / toluene / 0.33 h / Ambient temperature 5: TiCl4, molecular sieves / CH2Cl2 / 1 h / -78 °C 6: 93 percent / aq. HCl / ethyl acetate / 13 h / 100 °C View Scheme
参考文献
Takemoto; Matsumoto; Ito; Terashima
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2425 - 2428
反应条件
1: 59.6 percent / IBCF, NMM 2: 93 percent / 1 N NaOH / H2O; dioxane / 2 h / Ambient temperature View Scheme
参考文献
Adhikari, Bimalendu; Kraatz, Heinz-Bernhard
Chemical Communications, 2014 , vol. 50, # 42 p. 5551 - 5553
反应条件
hydrogen; Nishimura catalyst <(45.9percent Rh/19.9percent Pt) oxide> in methanol T=25°C; P=75007.5 Torr;
参考文献
Advanced Synthesis and Catalysis, , vol. 343, # 8 p. 802 - 808
反应条件
1: aqueous ethyl acetate / weiteres Edukt: Aethinyl-aethyl-aether 2: ethanol; aqueous KOH View Scheme
参考文献
Berse,C. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 3489 - 3495
反应条件
(i) Et3N, TsCl, (ii) aq. NaOH; Multistep reaction;
参考文献
Theodoropoulos,D.; Gazopoulos,J.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2091 - 2093
反应条件
1.1: BOP; DiPEA / dimethylformamide / 0.25 h 1.2: 70 percent / dimethylformamide / 1 h 2.1: 69 percent / aq. NaOH / dioxane; methanol / 1 h View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 9 p. 1416 - 1426
反应条件
1.1: 91 percent / aq. Na2CO3 / toluene / 1 h / 5 - 10 °C 2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 3.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C 4.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 5.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
反应条件
1.1: sodium carbonate / water; ethyl acetate / 0 - 16 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.03 h / 0 °C 2.2: 2 h / 20 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 1 p. 319 - 322
反应条件
hydrogenchloride; anhydrous calcium acetate; triethylamine; thermolysin in 1,1-dimethylpropan-1-ol T=40°C; 72 h;
参考文献
Ye, Yun-Hua; Tian, Gui-Ling; Xing, Guo-Wen; Dai, Dong-Cheng; Chen, Gang; Li, Chong-Xi
Tetrahedron, 1998 , vol. 54, # 41 p. 12585 - 12596
参考文献
Toyo Soda Manufacturing Co. Ltd.; (Zaidanhojin) Sagami Chemical Research Center
Patent: US4165311 A1, 1979 ;
