(S)-2-(苄氧羰氨基)-3-丁烯酸甲酯合成路线 （共 48 条）
反应条件
T=145°C; P=760 Torr; 72 h; Product distribution / selectivity;
参考文献
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.; LONG, Timothy, Edward; PATEL, Sravan, Kumar
Patent: WO2010/68371 A2, 2010 ;
Location in patent: Page/Page column 11; 29 ;
反应条件
T=145°C; P=760 Torr; 72 h;
参考文献
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.; LONG, Timothy, Edward; PATEL, Sravan, Kumar
Patent: WO2010/68371 A2, 2010 ;
Location in patent: Page/Page column 11; 29 ;
反应条件
T=145°C; P=3 Torr; 10 h;
参考文献
Patel, Sravan Kumar; Long, Timothy E.
Tetrahedron Letters, 2009 , vol. 50, # 36 p. 5067 - 5070
反应条件
sodium acetate in toluene 18 h; Reflux;
参考文献
Patel, Sravan Kumar; Long, Timothy E.
Tetrahedron Letters, 2009 , vol. 50, # 36 p. 5067 - 5070
反应条件
ozone in dichloromethane -78 deg C, then 76 deg C, 0.1 h;
参考文献
Barton, Derek H. R.; Crich, David; Herve, Yolande; Potier, Pierre; Thierry, Josiane
Tetrahedron, 1985 , vol. 41, # 19 p. 4347 - 4358
反应条件
hydrogenchloride T=0 - 22°C; methanolysis; 3 h;
参考文献
Wipf, Peter; Wenjing, Xu; Hongyong, Kim; Takahashi, Hidenori
Tetrahedron, 1997 , vol. 53, # 48 p. 16575 - 16596
反应条件
1: 92 percent / KHCO3 2: 84 percent / NaIO4 3: 20 percent / 1,2-dichloro-benzene / 160 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 2 p. 544 - 553
反应条件
1.1: 91 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C 2.1: 71 percent / dicyclohexylcarbodiimide; dimethylaminopyridine / CH2Cl2 / 12 h / 0 - 22 °C 3.1: 89 percent / MCPBA / CH2Cl2 / 4 h / 0 °C 4.1: 99 percent / AgClO4 / Cp2ZrCl2 / CH2Cl2 / 1 h / 22 °C 5.1: 82 percent / LiBH4; MeOH / diethyl ether / 0.25 h / Heating 6.1: 2-nitrophenyl selenocyanate; tri-n-butylphosphine / tetrahydrofuran / 0.25 h / 0 °C 6.2: 71 percent / aq. H2O2 / tetrahydrofuran / 6 h / 22 °C 7.1: 82 percent / HCl / 3 h / 0 - 22 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 48 p. 16575 - 16596
反应条件
1.1: 71 percent / dicyclohexylcarbodiimide; dimethylaminopyridine / CH2Cl2 / 12 h / 0 - 22 °C 2.1: 89 percent / MCPBA / CH2Cl2 / 4 h / 0 °C 3.1: 99 percent / AgClO4 / Cp2ZrCl2 / CH2Cl2 / 1 h / 22 °C 4.1: 82 percent / LiBH4; MeOH / diethyl ether / 0.25 h / Heating 5.1: 2-nitrophenyl selenocyanate; tri-n-butylphosphine / tetrahydrofuran / 0.25 h / 0 °C 5.2: 71 percent / aq. H2O2 / tetrahydrofuran / 6 h / 22 °C 6.1: 82 percent / HCl / 3 h / 0 - 22 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 48 p. 16575 - 16596
反应条件
1.1: 89 percent / KHCO3 / dimethylformamide / 12 h / 22 °C 2.1: 91 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C 3.1: 71 percent / dicyclohexylcarbodiimide; dimethylaminopyridine / CH2Cl2 / 12 h / 0 - 22 °C 4.1: 89 percent / MCPBA / CH2Cl2 / 4 h / 0 °C 5.1: 99 percent / AgClO4 / Cp2ZrCl2 / CH2Cl2 / 1 h / 22 °C 6.1: 82 percent / LiBH4; MeOH / diethyl ether / 0.25 h / Heating 7.1: 2-nitrophenyl selenocyanate; tri-n-butylphosphine / tetrahydrofuran / 0.25 h / 0 °C 7.2: 71 percent / aq. H2O2 / tetrahydrofuran / 6 h / 22 °C 8.1: 82 percent / HCl / 3 h / 0 - 22 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 48 p. 16575 - 16596
