4-羟基-N-(2-羟基乙基)苯甲酰胺合成路线 （共 8 条）
反应条件
T=103 - 107°C; 10.5 h;
参考文献
Juenge; Gurka; Kreienbaum
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 589 - 593
参考文献
Juenge; Gurka; Kreienbaum
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 589 - 593
反应条件
thionyl chloride; sodium hydrogencarbonate
参考文献
Sterling Drug Inc.
Patent: US4861791 A1, 1989 ;
反应条件
thionyl chloride in various solvent(s)
2 h;
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: 96 percent / SOCl2 / various solvent(s) / 2 h
2: 76 percent / K2CO3, NaI / acetonitrile / 21 h / Heating
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: 96 percent / SOCl2 / various solvent(s) / 2 h
2: 55 percent / K2CO3, NaI / acetonitrile / 21 h / Heating
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: 96 percent / SOCl2 / various solvent(s) / 2 h
2: 75 percent / K2CO3, NaI / acetonitrile / 21 h / Heating
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
反应条件
1: SOCl2 / various solvent(s) / 18 h / Ambient temperature
2: 69 percent / K2CO3, NaI / Heating
View Scheme
参考文献
Diana; McKinlay; Otto; Akullian; Oglesby
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910
