N-甲基吗啉氮氧化物合成路线

Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1

114615-82-6过钌酸四丙胺盐(TPAP)+

24424-99-5二碳酸二叔丁酯+

27489-62-9反式-4-氨基环己醇+

50910-54-8反式-4-氨基环己醇盐酸盐+

7529-22-8N-甲基吗啉氮氧化物

179321-49-44-N-Boc-氨基环己酮

参考文献

Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1

1229236-80-9+

7529-22-8N-甲基吗啉氮氧化物

1229236-83-2(4-氯-2-氟苯基)(6-氯-2-甲基-8-(吗啉甲基)咪唑并[1,2- b]吡嗪-3-基)甲酮

参考文献

ELI LILLY AND COMPANY
Patent: US2010/152181 A1, 2010 ;
Location in patent: Page/Page column 4 ;

1229236-80-9+

7529-22-8N-甲基吗啉氮氧化物

1229236-83-2(4-氯-2-氟苯基)(6-氯-2-甲基-8-(吗啉甲基)咪唑并[1,2- b]吡嗪-3-基)甲酮

参考文献

Mitchell, David; Cole, Kevin P.; Pollock, Patrick M.; Coppert, David M.; Burkholder, Timothy P.; Clayton, Joshua R.
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 70 - 81