1-Boc-3-乙烯基吡咯烷合成路线 （共 2 条）
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexanes T=0°C; 0.0833333 h; 2: 1-(t-butoxycarbonyl)-3-pyrrolidinecarboxaldehyde in tetrahydrofuran; hexanes T=0 - 20°C; 2.5 h;
参考文献
JANSSEN PHARMACEUTICA NV; BREITENBUCHER, Guy, J.; TICHENOR, Mark, S.; MERIT, Jeffrey, E.; HAWRYLUK, Natalie, A.; CHAMBERS, Alison, L.; KEITH, John, M.
Patent: WO2010/141809 A1, 2010 ;
Location in patent: Page/Page column 67-68 ;
WO 2010/141809 A1
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: 1-(t-butoxycarbonyl)-3-pyrrolidinecarboxaldehyde in tetrahydrofuran; hexane T=22°C; 2.5 h;
参考文献
US2004/176348 A1, ;
Page/Page column 10 ;
