2-氯-N-[2-(1,1-二甲基乙氧基)-2-(4-甲氧基苯基)乙基]-3,4-二甲氧基-苯乙胺合成路线 （共 13 条）
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
2: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl
2: 96 percent / dimethylsulfoxide / 1.25 h
3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
4: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: pyridine, 12 N aq. HCl, tert-butylhydroquinone / 1.5 h / 125 °C
2: 86.4 percent / Br2 / CH2Cl2 / -5 - 0 °C
3: 95 percent / MgSO4, MgO / 1.25 h / Heating
4: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
