2-乙酰基-4,5-二甲基噻唑合成路线 （共 5 条）
反应条件
1: 4,5-dimethyl-thiazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.16667 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-78°C; 2.16667 h; 3: With ammonium chloride in tetrahydrofuran; hexane; water 0.5 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1535910 A1, 2005 ;
Location in patent: Page/Page column 25 ;
EP 1535910 A1
反应条件
1: 4,5-dimethyl-thiazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: N,N-dimethyl acetamide in tetrahydrofuran T=-78 - 40°C; 3 h;
参考文献
Mutabilis
Patent: EP2141164 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 4,5-dimethyl-thiazole With n-butyllithium in diethyl ether; hexane T=-70 - -30°C; 1.33333 h; 2: ethyl acetate in tetrahydrofuran; hexane T=-70 - 20°C; 0.833333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/87699 A2, 2004 ;
Location in patent: Page 90 ;
WO 2004/087699 A2
反应条件
tert.-butylhydroperoxide in decane T=100°C; 16 h; Sealed tube;
参考文献
Khemnar, Ashok B.; Bhanage, Bhalchandra M.
Synlett, 2014 , vol. 25, # 1 art. no. ST-2013-D0840-L, p. 110 - 114
反应条件
diethyl ether anschliessend Behandeln mit Acetanhydrid;
参考文献
Bulletin de la Societe Chimique de France, , p. 702,705
