(R)-(-)-2-甲基哌嗪合成路线 （共 29 条）
反应条件
sodium hydroxide in branched octane; water T=80°C; 2 h;
参考文献
BIOVITRUM AB
Patent: WO2004/829 A1, 2003 ;
Location in patent: Page 25-26 ;
WO 2004/000829 A1
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol T=20°C; P=760 Torr; 24 h;
参考文献
Liu, Bo; Xu, Guang-Yu; Yang, Chun-Hao; Wu, Xi-Han; Xie, Yu-Yuan
Synthetic Communications, 2004 , vol. 34, # 22 p. 4111 - 4118
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
参考文献
Schanen, Vincent; Riche, Claude; Chiaroni, Angele; Quirion, Jean-Charles; Husson, Henri-Philippe
Tetrahedron Letters, 1994 , vol. 35, # 16 p. 2533 - 2536
反应条件
1: H2 / 10percent Pd/C / methanol / 18 h / 3040 Torr 2: BH3*THF / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
1: CF3COOH 2: 100 percent / H2, HCl / Pd/C / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 16 p. 2533 - 2536
反应条件
1: BH3 / tetrahydrofuran 2: CF3COOH 3: 100 percent / H2, HCl / Pd/C / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 16 p. 2533 - 2536
反应条件
1: 78 percent / triethylamine / methanol / 20 h / Heating 2: 81 percent / lithium aluminum hydride / tetrahydrofuran / 36 h / 0 - 20 °C 3: 76 percent / hydrogen; acetic acid / palladium on carbon / methanol / 24 h / 20 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 34, # 22 p. 4111 - 4118
反应条件
1: 81 percent / lithium aluminum hydride / tetrahydrofuran / 36 h / 0 - 20 °C 2: 76 percent / hydrogen; acetic acid / palladium on carbon / methanol / 24 h / 20 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 34, # 22 p. 4111 - 4118
反应条件
borane-THF in tetrahydrofuran 16 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
palladium on magnesium oxide in acetonitrile T=160°C; 20 h; AutoclaveInert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 254 - 260
