(R)-(-)-2-甲基哌嗪合成路线

参考文献

Gore, Vijay Keshav; Ma, Vu Van; Norman, Mark H.; Ognyanov, Vassil I.; Xi, Ning
Patent: US2006/84640 A1, 2006 ;
Location in patent: Page/Page column 15 ;

24424-99-5二碳酸二叔丁酯+

75336-86-6(R)-(-)-2-甲基哌嗪

163765-44-4(R)-4-Boc-2-甲基哌嗪

参考文献

PIRAMED LIMITED; GENENTECH, INC.; BAYLISS, Tracy; CHUCKOWREE, Irina; FOLKES, Adrian; OXENFORD, Sally; WAN, Nan, Chi; CASTANEDO, Georgette; GOLDSMITH, Richard; GUNZNER, Janet; HEFFRON, Tim; MATHIEU, Simon; OLIVERO, Alan; STABEN, Steven; SUTHERLIN, Daniel, P.; ZHU, Bing-Yan
Patent: WO2008/70740 A1, 2008 ;
Location in patent: Page/Page column 191 ;

75336-86-6(R)-(-)-2-甲基哌嗪

163765-44-4(R)-4-Boc-2-甲基哌嗪

参考文献

Millennium Pharmaceuticals, Inc.
Patent: US2003/153556 A1, 2003 ;
US 20030153556 A1

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈+

75336-86-6(R)-(-)-2-甲基哌嗪

163765-44-4(R)-4-Boc-2-甲基哌嗪

参考文献

PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; WILD, Carl; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; KIMBER, Marc; MAGARACI, Filippo; JOHNSTON, David
Patent: WO2008/134035 A1, 2008 ;
Location in patent: Page/Page column 123; 142 ;

403-33-8对氟苯甲酸甲酯+

75336-86-6(R)-(-)-2-甲基哌嗪

1201670-92-9(R)-4-(3-甲基哌嗪-1-基)苯甲酸甲酯

参考文献

AstraZeneca AB
Patent: US2009/318468 A1, 2009 ;
Location in patent: Page/Page column 11 ;

99747-74-71-萘基三氟甲磺酸酯+

75336-86-6(R)-(-)-2-甲基哌嗪

439081-68-2

参考文献

Lopez-Rodriguez, Maria L.; Morcillo, Maria Jose; Fernandez, Esther; Benhamu, Bellinda; Tejada, Ignacio; Ayala, David; Viso, Alma; Campillo, Mercedes; Pardo, Leonardo; Delgado, Mercedes; Manzanares, Jorge; Fuentes, Jose A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2548 - 2558

109-04-6邻溴吡啶+

75336-86-6(R)-(-)-2-甲基哌嗪

474417-44-2(3R)-3-甲基-1-(2-吡啶基)哌嗪

参考文献

Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey
Patent: US2002/169167 A1, 2002 ;

109-09-12-氯吡啶+

75336-86-6(R)-(-)-2-甲基哌嗪

474417-44-2(3R)-3-甲基-1-(2-吡啶基)哌嗪

参考文献

Applied Research Systems ARS Holding N.V.
Patent: WO2006/10751 A1, 2006 ;
Location in patent: Page/Page column 73 ;

75336-86-6(R)-(-)-2-甲基哌嗪+

65753-47-12-氯-3-三氟甲基吡啶

582325-05-1

参考文献

Ognyanov, Vassil I.; Balan, Chenera; Bannon, Anthony W.; Bo, Yunxin; Dominguez, Celia; Fotsch, Christopher; Gore, Vijay K.; Klionsky, Lana; Ma, Vu V.; Qian, Yi-Xin; Tamir, Rami; Wang, Xianghong; Xi, Ning; Xu, Shimin; Zhu, Dawn; Gavva, Narender R.; Treanor, James J. S.; Norman, Mark H.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3719 - 3742