2-(氯甲基)-5-甲氧基吡啶合成路线 （共 5 条）
反应条件
thionyl chloride in dichloromethane T=25°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
1: AcOH / 120 °C 2: 2N aq. NaOH / methanol / 2 h / 25 °C 3: SOCl2 / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
1: 2N aq. NaOH / methanol / 2 h / 25 °C 2: SOCl2 / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
triethylamine; trichlorophosphate in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 5 p. 453 - 458
反应条件
1.1: water; dimethyl sulfoxide / 20 °C 2.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / 20 °C / Cooling with ice 3.1: potassium hydroxide; water / ethylene glycol / 120 °C 3.2: Cooling with ice View Scheme
参考文献
Astellas Pharma Inc.; KAWAMINAMI Eiji; TAKAHASHI Tatsuhisa; KANAYAMA Takatoshi; SAKAMOTO Kazuyuki
Patent: EP2620433 A1, 2013 ;
