11-(1-哌嗪基)二苯并[b,f][1,4]硫氮杂卓盐酸盐(1:1)合成路线 （共 6 条）
反应条件
sodium hydroxide in water; toluene T=70°C; 0.75 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73360 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
WO 2006/073360 A1
反应条件
sodium carbonate; sodium iodide; tetrabutylammomium bromide in toluene T=115 - 120°C; 17 h; Heating / reflux;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2004/76431 A1, 2004 ;
Location in patent: Page 12-13 ;
反应条件
1: 10,11-dihydro-11-oxodibenz[b,f][1,4]thiazepine With trichlorophosphate in toluene
T=10°C; 4 h; Heating / reflux;
2: With potassium carbonate in water; toluene
T=15°C;
3: piperazine With hydrogenchloride
more than 3 stages;
参考文献
USV LIMITED
Patent: WO2007/4234 A1, 2007 ;
Location in patent: Page/Page column 12 ;
反应条件
hydrogenchloride in water
T=70°C; 0.75 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73360 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
WO 2006/073360 A1
反应条件
1: 2-(2-aminophenylthio)benzoic acid hydrochloride With trichlorophosphate in toluene
T=90°C; 2 h;
2: With N,N-dimethyl-aniline in toluene
2 h; Heating / reflux;
3: piperazine in toluene
1 h; Heating / reflux;
参考文献
SK CORPORATION
Patent: WO2006/1619 A1, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrogenchloride in isopropyl alcohol; toluene
参考文献
Niphade, Navnath C.; Mali, Anil C.; Pandit, Bhushan S.; Jagtap, Kunal M.; Jadhav, Sanjay A.; Jachak, Madhukar N.; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 792 - 797
