(3-甲基哌嗪-1-基)-苯基甲基酮合成路线 （共 8 条）
反应条件
sodium hydrogencarbonate in acetone
T=20°C; 1.5 h;
参考文献
Manetti; Ghelardini; Bartolini; Dei; Galeotti; Gualtieri; Romanelli; Teodori
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4499 - 4507
反应条件
in tetrahydrofuran
T=0°C; 36 h;
参考文献
Kondo, Kazuhiro; Murakami, Yasuoki
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1217 - 1219
反应条件
in tetrahydrofuran
1.) 0 deg C, 24 h, 2.) r.t., 12 h;
参考文献
Kondo, Kazuhiro; Sekimoto, Erika; Nakao, Junko; Murakami, Yasuoki
Tetrahedron, 2000 , vol. 56, # 32 p. 5843 - 5856
反应条件
1: rac-2-methylpiperazine With n-butyllithium in tetrahydrofuran
T=20°C; Metallation; 0.5 h;
2: benzoyl chloride in tetrahydrofuran
T=20°C; benzoylation; 0.166667 h; Further stages.;
参考文献
Wang, Tao; Zhang, Zhongxing; Meanwell, Nicholas A.
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4740 - 4742
反应条件
T=0°C; Acylation; 18 h;
参考文献
Kondo, Kazuhiro; Sekimoto, Erika; Nakao, Junko; Murakami, Yasuoki
Tetrahedron, 2000 , vol. 56, # 32 p. 5843 - 5856
反应条件
in chloroform
0.25 h; Heating;
参考文献
Armarego, Wilfred L. F.; Schou, Henning; Waring, Paul
Journal of Chemical Research, Miniprint, 1980 , # 4 p. 1951 - 1966
反应条件
1: 1.) BuLi / 1.) THF, 23 deg C, 20 min, 2.) THF, 23 deg C, 1 h
2: 94 percent / tetrahydrofuran / 36 h / 0 °C
View Scheme
参考文献
Kondo, Kazuhiro; Murakami, Yasuoki
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1217 - 1219
反应条件
1: 92 percent / pyridine / Ambient temperature
2: 93 percent / tetrahydrofuran / 1.) 0 deg C, 24 h, 2.) r.t., 12 h
View Scheme
参考文献
Kondo, Kazuhiro; Sekimoto, Erika; Miki, Kazuki; Murakami, Yasuoki
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 18 p. 2973 - 2974
