Boc-L-天冬氨酸 4-苄酯合成路线 （共 36 条）
反应条件
1: H2SO4 / diethyl ether 2: triethylamine / tetrahydrofuran View Scheme
参考文献
Doklady Chemistry, , vol. 408, # 1 p. 57 - 60
反应条件
1: base 2: 91 percent / piperidine / acetonitrile / Ambient temperature View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 26, # 2 p. 196 - 198
Khimiya Prirodnykh Soedinenii, , # 2 p. 241 - 245
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Justus Liebigs Annalen der Chemie, , vol. 716, p. 175 - 185
反应条件
triethylamine in dimethyl sulfoxide
参考文献
Bulletin de la Societe Chimique de France, , p. 2543 - 2546
反应条件
Nafion H; trifluoroacetic acid 3 h;
参考文献
Kiso; Yoshida; Tatsumi; Kimura; Fujiwara; Akaji
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 12 p. 3432 - 3434
反应条件
1: 85 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH2Cl2 / 2 h / 20 °C 2: 100 percent / H2 / Pd/C / ethanol / 1 h / 2585.74 Torr View Scheme
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; KUNG, Hank, F.; THOMPSON, Craig, B.; QU, Wenchao; PLOESSL, Karl
Patent: WO2011/20018 A1, 2011 ;
参考文献
Hlavacek, Jan; Pirkova, Jana; Pospisek, Jan; Slaninova, Jirina; Maletinska, Lenka
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 10 p. 2209 - 2217
反应条件
1: triethylamine / tetrahydrofuran / 0 °C 2: sodium tetrahydroborate / water / 1 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / 20 °C View Scheme
参考文献
Yoshikawa, Kenji; Yoshino, Toshiharu; Yokomizo, Yoshihiro; Uoto, Kouichi; Naito, Hiroyuki; Kawakami, Katsuhiro; Mochizuki, Akiyoshi; Nagata, Tsutomu; Suzuki, Makoto; Kanno, Hideyuki; Takemura, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2133 - 2140
反应条件
1: With triethylamine in tetrahydrofuran 2: With sodium tetrahydroborate in water
参考文献
Sugiyama, Hideyuki; Shioiri, Takayuki; Yokokawa, Fumiaki
Tetrahedron Letters, 2002 , vol. 43, # 19 p. 3489 - 3492
反应条件
1: 85 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH2Cl2 / 2 h / 20 °C 2: 100 percent / H2 / Pd/C / ethanol / 1 h / 2585.74 Torr 3: 80 percent / BH3*THF / tetrahydrofuran / 1 h / -15 °C View Scheme
参考文献
Tetrahedron, , vol. 57, # 30 p. 6557 - 6566
