2-(2-氯-3,4-二甲氧基苯基)乙腈合成路线 （共 16 条）
反应条件
1: 97 percent / 12N aq. HCl
2: 96 percent / dimethylsulfoxide / 1.25 h
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
4: 97 percent / 12N aq. HCl
5: 96 percent / dimethylsulfoxide / 1.25 h
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
3: 97 percent / 12N aq. HCl
4: 96 percent / dimethylsulfoxide / 1.25 h
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 1.) N,N,N'-trimethylethylenediamine, n-BuLi, 2.) hexachloroethane / 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
3: 84 percent / SOCl2 / 24 h / Heating
4: 67 percent / 18-crown-6 / acetonitrile / 168 h / Heating
View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
2: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
2: 37 percent / 2.5 h / Heating
3: TFA, 36 N aq. H2SO4 / 3.5 h / 25 °C
4: BBr3 / CH2Cl2 / 3 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
