2-(四氢-2H-吡喃-2-基)乙腈合成路线 （共 9 条）
反应条件
lithium aluminium tetrahydride in diethyl ether 72 h;
参考文献
Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 27 ;
US 20040087601 A1
反应条件
chloro-trimethyl-silane; sodium iodide in N,N-dimethyl-formamide; acetonitrile
T=60 - 65°C; 2.5 h;
参考文献
Davis, Roman; Untch, Karl G.
Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2985 - 2987
反应条件
tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide
T=80°C; 3 h;
参考文献
Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 27 ;
US 20040087601 A1
反应条件
MS in ethanol
72 h; Heating;
参考文献
Fleming; Wang; Steward
Journal of Organic Chemistry, 2001 , vol. 66, # 6 p. 2171 - 2174
参考文献
Pfizer Inc.
Patent: US4476131 A1, 1984 ;
反应条件
potassium tert-butylate
T=180°C;
参考文献
Maciejewski, Lucien; Brocard, Jacques; Glacet, Charles
Bulletin de la Societe Chimique de France, 1980 , vol. 2, p. 255 - 260
反应条件
1: 98 percent / NaOH
2: 70 percent / MS / ethanol / 72 h / Heating
View Scheme
参考文献
Fleming; Wang; Steward
Journal of Organic Chemistry, 2001 , vol. 66, # 6 p. 2171 - 2174
反应条件
1: diisobutylaluminum hydride (DIBAL-H) / toluene / 1 h / -70 °C
2: 1.) sodium hydride / 1.) dioxane, 5 deg C, 2.) dioxane, 25 deg C, 2 h
View Scheme
参考文献
Passarotti; Valenti; Ceriani; Grianti
Bollettino Chimico Farmaceutico, 1993 , vol. 132, # 5 p. 150 - 152
反应条件
sodium hydride
1.) dioxane, 5 deg C, 2.) dioxane, 25 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Passarotti; Valenti; Ceriani; Grianti
Bollettino Chimico Farmaceutico, 1993 , vol. 132, # 5 p. 150 - 152
