3-[(1R)-3-[双(1-甲基乙基)氨基]-1-苯基丙基]-4-(苯基甲氧基)苯甲酸合成路线 （共 4 条）
反应条件
1: sulfuric acid / 20 °C / Reflux 2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / Inert atmosphere 3: hydrogen / Raney nickel / methanol / 20 °C View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; VERMA, Shyam Sunder; HANDIQUE, Sourav; AHUJA, Seema; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/46135 A1, 2013 ;
反应条件
1: sulfuric acid / 20 °C / Reflux 2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / Inert atmosphere 3: hydrogen / Raney nickel / methanol / 20 °C 4: triethylamine / acetonitrile / -10 °C View Scheme
反应条件
sulfuric acid T=20°C; Reflux; Product distribution / selectivity;
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; REGURI, Buchi, Reddy; UPPARAPALLI, Sampath, Kumar; SAHU, Nilam; KRISHNASAMY, Mariappan; GNANI PEER MOHAMED, Syed, Ibrahim; SWAMINATHAN, Susi
Patent: WO2011/145019 A1, 2011 ;
Location in patent: Page/Page column 21-22 ;
反应条件
Stage #1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=30 - 55°C; Stage #2: With water; sodium hydroxide in toluene T=0 - 5°C; 0.333333 h; Show Experimental Procedure
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; REGURI, Buchi, Reddy; UPPARAPALLI, Sampath, Kumar; SAHU, Nilam; KRISHNASAMY, Mariappan; GNANI PEER MOHAMED, Syed, Ibrahim; SWAMINATHAN, Susi Patent: WO2011/145019 A1, 2011 ; Location in patent: Page/Page column 24 ;
