1: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h 2: methyltriphenoxyphosphonium iodide 3: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 4: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 5: BF3 etherate / diethyl ether 6: 30 percent / aq. 3N HCl View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 90 percent / MCPBA / CH₂Cl₂ / 20 h / Heating<br />2: 97 percent / HCl / 3 h / 25 &deg;C<br />3: 85 percent / diisopropylethylamine / 18 h / 150 &deg;C / other reaction conditions<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 97 percent / HCl / 3 h / 25 &deg;C<br />2: 85 percent / diisopropylethylamine / 18 h / 150 &deg;C / other reaction conditions<br /> <br /> &nbsp;