反应条件
1: pyridine-2-carboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; Inert atmosphere;
2: mono-methyl malonate potassium salt With magnesium chloride in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Liu, Longbin; Norman, Mark H.; Lee, Matthew; Xi, Ning; Siegmund, Aaron; Boezio, Alessandro A.; Booker, Shon; Choquette, Debbie; D'Angelo, Noel D.; Germain, Julie; Yang, Kevin; Yang, Yajing; Zhang, Yihong; Bellon, Steven F.; Whittington, Douglas A.; Harmange, Jean-Christophe; Dominguez, Celia; Kim, Tae-Seong; Dussault, Isabelle
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1868 - 1897