1.1: 98 percent / nBu4NF / tetrahydrofuran / 6 h / 23 °C 2.1: 84 percent / tris(3-chlorophenyl)phosphine; DIAD / toluene / 3 h / 23 °C 3.1: 91 percent / EtiPr2N; TBAI / dimethylformamide / 3 h / 80 °C 4.1: LDA / tetrahydrofuran / -78 °C 4.2: 81 percent / tetrahydrofuran / cooling 5.1: aq. H2O2 / various solvent(s) / 3 h / 23 °C 6.1: 249 mg / toluene / 1 h / 80 °C 7.1: 87 percent / PhCH=Ru{[(MeS)NCH2CH2N(MeS)]}(PCy3)Cl2 / toluene / 0.17 h / Heating 8.1: 68 percent / SO2Cl2 / diethyl ether / 1.5 h / 0 °C 9.1: 74 percent / aq. HCl / dioxane / 1 h / 0 - 23 °C 10.1: 86 percent / K2CO3 / dimethylformamide / 1 h / 23 °C View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1.1: 98 percent / imidazole / 2-methyl-propan-2-ol / 4 h / 23 &deg;C<br />2.1: O₃ / CH₂Cl₂ / 0.08 h / -78 &deg;C<br />2.2: 94 percent / PPh₃ / CH₂Cl₂ / 2 h / 23 &deg;C<br />3.1: 68 percent / LiNc-Hex; IpcBOMe; BF₃*Et₂O / 4 h / -95 &deg;C<br />4.1: 97 percent / DBU / CH₂Cl₂ / 8 h / 0 &deg;C<br /> <br /> &nbsp;