7-氮杂吲哚-5-硼酸频哪醇酯合成路线 （共 5 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=80°C; 10 h;
参考文献
US2008/153860 A1, ;
Page/Page column 24 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; dichloromethane T=150°C; 0.333333 h; Microwave irradiation;
参考文献
WO2006/63167 A1, ;
Page/Page column 67-68 ;
WO 2006/063167 A1
反应条件
1: 5-(4,4,5,5-tetramethyl-1,3 ,2-dioxaborolan-2-yl)- 1 H-pyrrolo[2,3-b]pyridine With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
NOVARTIS AG; FURET, Pascal; IMBACH, Patricia; MAH, Robert; STAUFFER, Frederic
Patent: WO2010/139747 A1, 2010 ;
Location in patent: Page/Page column 106 ;
WO 2010/139747 A1
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate in ethylene glycol dimethyl ether; water
4 h; Inert atmosphereReflux;
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Xiaobo; ZHOU, Shiqing
Patent: WO2014/89280 A1, 2014 ;
Location in patent: Page/Page column 58-59 ;
反应条件
triethylamine; copper diacetate in dichloromethane
T=20°C; Chan-Lam Coupling; 120 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/72896 A1, 2007 ;
Location in patent: Page/Page column 54 ;
