2-氨基-3-苄氧-5-溴吡啶合成路线 （共 6 条）
反应条件
bromine in chloroform T=0°C;
参考文献
Hinklin, Ronald J.; Boyd, Steven A.; Chicarelli, Mark J.; Condroski, Kevin R.; Dewolf, Walter E.; Lee, Patrice A.; Lee, Waiman; Singh, Ajay; Thomas, Laurie; Voegtli, Walter C.; Williams, Lance; Aicher, Thomas D.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7669 - 7678
反应条件
caesium carbonate in N,N-dimethyl-formamide T=80°C; 4 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 18 p. 6342 - 6363
反应条件
1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 6 h / 20 °C 2: sulfuric acid; bromine; acetic acid / water / 0 - 20 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 344, # 3 p. 158 - 164
反应条件
hydrogenchloride; acetic acid in water RefluxInert atmosphere;
参考文献
Chen, Dong; Liu, Yajing; Zhang, Shulan; Guo, Dexiang; Liu, Chunhong; Li, Sai; Gong, Ping
Archiv der Pharmazie, 2011 , vol. 344, # 3 p. 158 - 164
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dichloromethane; dimethyl sulfoxide
T=80°C; 16 h;
参考文献
PFIZER INC.
Patent: WO2006/21886 A1, 2006 ;
Location in patent: Page/Page column 65 ;
WO 2006/021886 A1
反应条件
copper(l) iodide; iodine; 1,2-dichloro-ethane; isopentyl nitrite
T=85°C; 0.166667 h;
参考文献
Verdelet, Tristan; Mercey, Guillaume; Correa, Nobi; Jean, Ludovic; Renard, Pierre-Yves
Tetrahedron, 2011 , vol. 67, # 45 p. 8757 - 8762
