6-氯-4-氧代-10-丙基吡喃并[5,6-g]喹啉-2,8-二羧酸二钠合成路线 (共 9 条)
反应条件
sodium hydrogencarbonate in water; acetone
参考文献
Fisons Limited
Patent: US4419352 A1, 1983 ;
反应条件
1: 81 percent / potassium carbonate / dimethylformamide / 5 h
2: 70 percent / various solvent(s) / 4 h / Heating
3: 98 percent / H2 / PtO2 / acetic acid / 2206.5 Torr
4: 1.) EtONa, 2.) conc. HCl / 1.) ethanol, reflux, 2 h, 2.) ethanol, reflux, 15 h
5: 57 percent / ethanol / 17 h / Heating
6: 81 percent / diphenyl ether / 0.08 h / Heating
7: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
8: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
1: 70 percent / various solvent(s) / 4 h / Heating
2: 98 percent / H2 / PtO2 / acetic acid / 2206.5 Torr
3: 1.) EtONa, 2.) conc. HCl / 1.) ethanol, reflux, 2 h, 2.) ethanol, reflux, 15 h
4: 57 percent / ethanol / 17 h / Heating
5: 81 percent / diphenyl ether / 0.08 h / Heating
6: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
7: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
1: 98 percent / H2 / PtO2 / acetic acid / 2206.5 Torr
2: 1.) EtONa, 2.) conc. HCl / 1.) ethanol, reflux, 2 h, 2.) ethanol, reflux, 15 h
3: 57 percent / ethanol / 17 h / Heating
4: 81 percent / diphenyl ether / 0.08 h / Heating
5: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
6: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
sodium hydroxide in methanol
0.25 h; Heating;
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
1: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
2: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
1: 57 percent / ethanol / 17 h / Heating
2: 81 percent / diphenyl ether / 0.08 h / Heating
3: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
4: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
1: 81 percent / diphenyl ether / 0.08 h / Heating
2: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
3: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842
反应条件
1: 1.) EtONa, 2.) conc. HCl / 1.) ethanol, reflux, 2 h, 2.) ethanol, reflux, 15 h
2: 57 percent / ethanol / 17 h / Heating
3: 81 percent / diphenyl ether / 0.08 h / Heating
4: 59 percent / POCl3 / benzene / 25 h / Ambient temperature
5: 0.1 M NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Cairns, Hugh; Cox, David; Gould, Ken J.; Ingall, Anthony H.; Suschitzky, John L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1832 - 1842