2'-溴-2,6-二甲氧基联苯合成路线 （共 10 条）
反应条件
1: 2‐bromo‐2’,6’‐dimethoxybiphenyl With n-butyllithium in tetrahydrofuran T=-78°C; 1.5 h; Inert atmosphereCooling with acetone-dry ice; 2: chloro-dicyclohexylphosphine in tetrahydrofuran T=20 - 45°C; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 32 p. 5841 - 5844
反应条件
1: 1,3-dimethoxy benzene With n-butyllithium in tetrahydrofuran; hexane
T=20°C; 5 h;
2: 1-bromo-2-chloro-benzene in tetrahydrofuran; hexane
T=0°C; 0.5 h;
参考文献
Barder, Timothy E.; Walker, Shawn D.; Martinelli, Joseph R.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2005 , vol. 127, # 13 p. 4685 - 4696
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=25°C; 3 h; Inert atmosphere; regioselective reaction;
参考文献
Diemer, Vincent; Garcia, Juan Sanz; Leroux, Frederic R.; Colobert, Francoise
Journal of Fluorine Chemistry, 2012 , vol. 134, p. 146 - 155
反应条件
1: 1,3-dimethoxy benzene With n-butyllithium in tetrahydrofuran; hexane
T=20°C; 1 h;
2: ortho-dibromobenzene in tetrahydrofuran; hexane
T=20°C; 3 h; Further stages.;
参考文献
Xu, Hanhui; Ekoue-Kovi, Kekeli; Wolf, Christian
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7638 - 7650
反应条件
triphenyl-arsane; silver carbonate; palladium dichloride in dimethyl sulfoxide
T=150°C; 6 h;
参考文献
Becht, Jean-Michel; Catala, Cedric; Le Drian, Claude; Wagner, Alain
Organic Letters, 2007 , vol. 9, # 9 p. 1781 - 1783
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=25°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Diemer, Vincent; Garcia, Juan Sanz; Leroux, Frederic R.; Colobert, Francoise
Journal of Fluorine Chemistry, 2012 , vol. 134, p. 146 - 155
反应条件
1: 1,3-dimethoxy benzene With n-butyllithium in tetrahydrofuran; hexane
T=20°C; 1 h;
2: ortho-fluorobromobenzene in tetrahydrofuran; hexane
T=20°C; 3 h; Further stages.;
参考文献
Becht, Jean-Michel; Ngouela, Silvere; Wagner, Alain; Mioskowski, Charles
Tetrahedron, 2004 , vol. 60, # 32 p. 6853 - 6857
反应条件
1: 1,3-dimethoxy benzene With n-butyllithium in tetrahydrofuran; hexane
T=0 - 25°C; 5 h; Inert atmosphere;
2: ortho-dibromobenzene in tetrahydrofuran; hexane
T=0 - 25°C; Inert atmosphere;
参考文献
Diemer, Vincent; Begaud, Manon; Leroux, Frederic R.; Colobert, Fracoise
European Journal of Organic Chemistry, 2011 , # 2 p. 341 - 354
反应条件
1: tetrahydrofuran / 3 h / -35 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Diemer, Vincent; Garcia, Juan Sanz; Leroux, Frederic R.; Colobert, Francoise
Journal of Fluorine Chemistry, 2012 , vol. 134, p. 146 - 155
反应条件
1: tetrahydrofuran / 3 h / -35 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Diemer, Vincent; Garcia, Juan Sanz; Leroux, Frederic R.; Colobert, Francoise
Journal of Fluorine Chemistry, 2012 , vol. 134, p. 146 - 155
