(7R)-2-氯-8-环戊基-7-乙基-7,8-二氢-5-甲基-6(5H)-蝶啶酮合成路线 （共 3 条）
反应条件
toluene-4-sulfonic acid in methyl-isobutyl-carbinol 5 h; Heating / reflux;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/35902 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
1.1: hydrogenchloride / ethanol; water / 48 h / Inert atmosphere; Reflux 2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 2.2: 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Budin, Ghyslain; Yang, Katherine S.; Reiner, Thomas; Weissleder, Ralph
Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9378 - 9381
反应条件
hydrogenchloride in ethanol; water
48 h; Inert atmosphereReflux;
参考文献
Budin, Ghyslain; Yang, Katherine S.; Reiner, Thomas; Weissleder, Ralph
Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9378 - 9381
