6-(苯基甲基)-7,8-二氢-5H-1,6-萘啶合成路线 （共 10 条）
反应条件
1: H2; AcOH / Pd/C / 2 h / 50 - 60 °C 2: 981 mg / aq. NaOH / toluene / 0.17 h 3: 98 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 4: 88 percent / N,N-dimethylcarbamyl chloride / CH2Cl2 / 41 h / 20 °C View Scheme
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182
反应条件
hydrogen; palladium on activated charcoal in acetic acid T=50 - 60°C;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 7 p. 2522 - 2529
反应条件
triethylamine; piperidinium acetate
T=120°C; 24 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/56556 A1, 2009 ;
Location in patent: Page/Page column 40-41 ;
WO 2009/056556 A1
反应条件
Li2CuCl4 in ethanol
T=78°C; 7 h;
参考文献
Abbiati, Giorgio; Arcadi, Antonio; Bianchi, Gabriele; Di Giuseppe, Sabrina; Marinelli, Fabio; Rossi, Elisabetta
Journal of Organic Chemistry, 2003 , vol. 68, # 18 p. 6959 - 6966
反应条件
sodium borohydride in methanol; water; acetonitrile
参考文献
Pfizer Inc.
Patent: US5037834 A1, 1991 ;
反应条件
sodium tetrahydroborate in methanol; water
Ambient temperature;
参考文献
Shiozawa; Ichikawa; Ishikawa; et al.
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 995 - 1005
反应条件
piperidinium acetate; triethylamine
T=120°C; 24 h;
参考文献
Shiozawa; Ichikawa; Komuro; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 7 p. 2522 - 2529
反应条件
acetic acid-pyridine; triethylamine
T=120°C; 22 h;
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182
反应条件
1: acetonitrile / Heating
2: 80 percent / NaBH4 / methanol; H2O / Ambient temperature
View Scheme
参考文献
Shiozawa; Ichikawa; Ishikawa; et al.
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 995 - 1005
反应条件
1: 1.) LDA / 1.) THF, 1 h, -68 deg C; 2.) THF, 15 min, -55 deg C
2: 92 percent / H2 / Pd-C / acetic acid / 50 - 60 °C
View Scheme
参考文献
Shiozawa; Ichikawa; Komuro; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 7 p. 2522 - 2529
