N-[(7R)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]乙酰胺合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in chloroform; water
2.5 h;
参考文献
Dumont; Brossi; Silverton
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
反应条件
1: 79 percent / Na2CO3 / diethyl ether / 2.5 h / Ambient temperature
2: 46 percent / methanol; diethyl ether / 3 h
3: 70 percent / K2CO3 / acetone; H2O / 60 °C
5: 80 percent / NaHCO3 / CHCl3; H2O / 2.5 h
View Scheme
参考文献
Dumont; Brossi; Silverton
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
反应条件
1: 50 percent / 20percent H2SO4 / acetic acid / 5 h / 80 - 90 °C
2: 79 percent / Na2CO3 / diethyl ether / 2.5 h / Ambient temperature
3: 46 percent / methanol; diethyl ether / 3 h
4: 70 percent / K2CO3 / acetone; H2O / 60 °C
6: 80 percent / NaHCO3 / CHCl3; H2O / 2.5 h
View Scheme
参考文献
Dumont; Brossi; Silverton
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
反应条件
2: 80 percent / NaHCO3 / CHCl3; H2O / 2.5 h
View Scheme
参考文献
Dumont; Brossi; Silverton
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
反应条件
1: 46 percent / methanol; diethyl ether / 3 h
2: 70 percent / K2CO3 / acetone; H2O / 60 °C
4: 80 percent / NaHCO3 / CHCl3; H2O / 2.5 h
View Scheme
参考文献
Dumont; Brossi; Silverton
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
反应条件
1: 70 percent / K2CO3 / acetone; H2O / 60 °C
3: 80 percent / NaHCO3 / CHCl3; H2O / 2.5 h
View Scheme
参考文献
Dumont; Brossi; Silverton
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
反应条件
1: benzene / 1 h / 50 - 60 °C
2: diethyl ether
View Scheme
参考文献
Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
参考文献
Roesner et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, p. 257,260
参考文献
Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
反应条件
1: methanol. KOH
2: (1S)-2-oxo-bornane-10-sulfonic acid
3: pyridine
4: diethyl ether; CH2Cl2
View Scheme
参考文献
Corrodi; Hardegger
Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199
