1-苄基-4-(3-氟苯基)哌啶-4-醇合成路线 （共 4 条）
反应条件
magnesium
1.) THF, reflux, 1 h 2.) THF, reflux, 20 h; Yield given. Multistep reaction;
参考文献
Nagai, Yasutaka; Hino, Katsuhiko; Uno, Hitoshi; Minami, Shinsaku
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 5 p. 1387 - 1393
反应条件
in tetrahydrofuran
T=20°C; 2 h;
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 211; 212 ;
反应条件
hydrogenchloride in ethanol; water
50 h; Heating;
参考文献
Nagai, Yasutaka; Hino, Katsuhiko; Uno, Hitoshi; Minami, Shinsaku
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 5 p. 1387 - 1393
反应条件
palladium hydroxide on carbon; hydrogen in methanol
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 212 ;
