4-(3-硝基苯基)-2-二甲氧基甲基-1,4-二氢吡啶-3,5-二甲酸5-异丙基酯3-甲酯合成路线 （共 6 条）
反应条件
1: piperidine / benzene / 5 h / Heating 2: 3 h / 100 - 120 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 28 p. 5747 - 5754
反应条件
T=95 - 120°C; 8.5 h;
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
反应条件
1: piperidine / benzene / 5 h / Heating 2: 3 h / 100 - 120 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 28 p. 5747 - 5754
反应条件
in isopropyl alcohol cyclocondensation; Hantzsch synthesis; 10 h; Heating;
参考文献
Chudik, Miloslav; Marchalin, Stefan; Pham-Huu, Duy-Phong; Humpa, Otakar; Friedl, Zdenek
Monatshefte fur Chemie, 1999 , vol. 130, # 10 p. 1241 - 1252
反应条件
hydrogenchloride in acetone 1 h; Ambient temperature;
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
反应条件
1: 95.4 percent / 6 N aq. HCl / acetone / 1 h / Ambient temperature 2: 1.) NH2OH*HCl, NaOAc, 2.) Ac2O / 1.) AcOH, RT, 2.5 h, 2.) AcOH, a) RT, 1.5 h, b) 95 deg C - 100 deg C, 4 h View Scheme
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
