2-(2-溴-5-甲氧基苯基)乙醇合成路线 （共 13 条）
反应条件
1.1: potassium hexamethylsilazane / toluene / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 7 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; water / 12 h / Reflux
3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Wurst, Jacqueline M.; Liu, Guodong; Tan, Derek S.
Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 7916 - 7925
反应条件
1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere
2.1: potassium hexamethylsilazane / toluene / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 7 h / 0 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 12 h / Reflux
4.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Wurst, Jacqueline M.; Liu, Guodong; Tan, Derek S.
Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 7916 - 7925
反应条件
1.1: dimethylsulfide borane / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere
3.1: potassium hexamethylsilazane / toluene / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 7 h / 0 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; water / 12 h / Reflux
5.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Wurst, Jacqueline M.; Liu, Guodong; Tan, Derek S.
Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 7916 - 7925
