D-(+)-苹果酸二乙酯合成路线 （共 15 条）
反应条件
samarium diiodide; ethylene glycol in tetrahydrofuran 0.333333 h; Ambient temperature;
参考文献
Kusuda, Kazuhiro; Junji, Inanaga; Yamaguchi, Masaru
Tetrahedron Letters, 1989 , vol. 30, # 22 p. 2945 - 2948
反应条件
thionyl chloride Esterification;
参考文献
Claffey, Michelle M.; Hayes, Christopher J.; Heathcock, Clayton H.
Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8267 - 8274
反应条件
1: With dihydrogen peroxide in chloroform T=-20°C; 16 h; 2: With N-ethyl-N,N-diisopropylamine in chloroform T=30°C; 15 h; Further stages. Title compound not separated from byproducts.;
参考文献
Tetrahedron Letters, , vol. 48, # 34 p. 5976 - 5980
反应条件
water; zinc in acetone T=45°C; 7.5 h; Inert atmosphere;
参考文献
Szpilman, Alex M.; Cereghetti, Damiano M.; Manthorpe, Jeffrey M.; Wurtz, Nicholas R.; Carreira, Erick M.
Chemistry - A European Journal, 2009 , vol. 15, # 29 p. 7117 - 7128
反应条件
titanium tetraethoxide in ethanol
参考文献
Tetrahedron Letters, , vol. 42, # 1 p. 137 - 140
反应条件
1: 95 percent / 2,2-di-tert-butylperoxybutane (DBPB); tert-dodecanethiol (TDT); collidine / octane; chlorobenzene / 3 h / Heating 2: Ti(OEt)4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 1 p. 137 - 140
反应条件
1: 90 percent / N-bromosuccinimide (NBS), 48 percent HBr / CCl4 / 1 h / Heating 2: 88 percent / tributylzinnhydride, α,α'-azoisobutyronitrile / toluene / 2 h / 80 °C 3: 1.) tetraethyltitanate 2.) 2 N HCl / 1.) reflux, 8 h; 2.) CH2Cl2 + water View Scheme
参考文献
Helvetica Chimica Acta, , vol. 64, # 5 p. 1467 - 1487
反应条件
1: 88 percent / tributylzinnhydride, α,α'-azoisobutyronitrile / toluene / 2 h / 80 °C 2: 1.) tetraethyltitanate 2.) 2 N HCl / 1.) reflux, 8 h; 2.) CH2Cl2 + water View Scheme
参考文献
Helvetica Chimica Acta, , vol. 64, # 5 p. 1467 - 1487
反应条件
ethanol; nitrogen oxides T=45 - 50°C;
参考文献
Chemische Berichte, , vol. 68, p. 1654
反应条件
1: 85 percent / LiI / dimethylformamide / 2 h / Ambient temperature 2: 72 percent / Zn / ethanol / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3513 - 3514
