巨大戟醇-3-O-当归酸酯合成路线 （共 16 条）
反应条件
hydrogenchloride; methanol; water in tetrahydrofuran T=20°C; 6.5 h;
参考文献
WO2012/10172 A1, ;
Page/Page column 62 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=-20°C; 0.25 h; Inert atmosphere;
参考文献
WO2012/10172 A1, ;
Page/Page column 60 ;
反应条件
hydrogenchloride; water in methanol T=20°C; 0.5 h;
参考文献
WO2014/12836 A1, ;
Page/Page column 8 ;
反应条件
hydrogenchloride; water in methanol T=20°C; 1 h;
参考文献
Synlett, , vol. 23, # 18 p. 2647 - 2652
反应条件
1: toluene-4-sulfonic acid / 1.5 h / 20 °C 2: sodium hydrogencarbonate / toluene / 22 h / 100 °C 3: hydrogenchloride; water; methanol / 1 h / 20 °C View Scheme
反应条件
1: toluene-4-sulfonic acid / 1.5 h / 20 °C 2: sodium hydrogencarbonate / toluene / 22 h / 100 °C 3: water; methanesulfonic acid / tetrahydrofuran / 72 h / 20 °C View Scheme
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.82 h / 0 - 6 °C / Inert atmosphere 2: sodium hydrogencarbonate / toluene / 22 h / 100 °C 3: hydrogenchloride; water; methanol / 1 h / 20 °C View Scheme
反应条件
1: sodium hydrogencarbonate / toluene / 22 h / 100 °C 2: hydrogenchloride; water; methanol / 1 h / 20 °C View Scheme
反应条件
1: sodium hydrogencarbonate / toluene / 22 h / 100 °C 2: water; methanesulfonic acid / tetrahydrofuran / 72 h / 20 °C View Scheme
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.82 h / 0 - 6 °C / Inert atmosphere 2: sodium hydrogencarbonate / toluene / 22 h / 100 °C 3: water; methanesulfonic acid / tetrahydrofuran / 72 h / 20 °C View Scheme
