(4s)-4-(2-萘氧基)-L-脯氨酸甲酯合成路线 （共 4 条）
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol
T=20°C;
参考文献
Jorgensen, Malene R.; Olsen, Christian A.; Mellor, Ian R.; Usherwood, Peter N. R.; Witt, Matthias; Franzyk, Henrik; Jaroszewski, Jerzy W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 56 - 70
反应条件
1: 133 mg / Ph3P; DEAD / tetrahydrofuran / 20 °C
2: 86 percent / H2; glacial acetic acid / Pd/C / ethanol / 20 °C
View Scheme
参考文献
Jorgensen, Malene R.; Olsen, Christian A.; Mellor, Ian R.; Usherwood, Peter N. R.; Witt, Matthias; Franzyk, Henrik; Jaroszewski, Jerzy W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 56 - 70
反应条件
1: 133 mg / Ph3P; DEAD / tetrahydrofuran / 20 °C
2: 86 percent / H2; glacial acetic acid / Pd/C / ethanol / 20 °C
View Scheme
参考文献
Jorgensen, Malene R.; Olsen, Christian A.; Mellor, Ian R.; Usherwood, Peter N. R.; Witt, Matthias; Franzyk, Henrik; Jaroszewski, Jerzy W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 56 - 70
反应条件
1: Et3N / acetonitrile / 55 °C
2: 133 mg / Ph3P; DEAD / tetrahydrofuran / 20 °C
3: 86 percent / H2; glacial acetic acid / Pd/C / ethanol / 20 °C
View Scheme
参考文献
Jorgensen, Malene R.; Olsen, Christian A.; Mellor, Ian R.; Usherwood, Peter N. R.; Witt, Matthias; Franzyk, Henrik; Jaroszewski, Jerzy W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 56 - 70
