in ethanol T=20°C; 22 h;

1: 1.) Mg / 1.) ether, 2.) ether, 20 deg C, 3 h; reflux, 12 h 2: 80 percent / acetonitrile / 1.) reflux, 3 h, 2.) 20 deg C, 12 h 3: 77 percent / aq. ethanol / 22 h / 20 °C View Scheme

1: 91 percent / 5 h / Heating 2: 1.) Mg / 1.) ether, 2.) ether, 20 deg C, 3 h; reflux, 12 h 3: 80 percent / acetonitrile / 1.) reflux, 3 h, 2.) 20 deg C, 12 h 4: 77 percent / aq. ethanol / 22 h / 20 °C View Scheme

1: 78 percent / petroleum ether / 1.) reflux, 3 h, 2.) room temp., 12 h 2: 88 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 55 °C 3: 91 percent / 5 h / Heating 4: 1.) Mg / 1.) ether, 2.) ether, 20 deg C, 3 h; reflux, 12 h 5: 80 percent / acetonitrile / 1.) reflux, 3 h, 2.) 20 deg C, 12 h 6: 77 percent / aq. ethanol / 22 h / 20 °C View Scheme

1: 88 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 55 °C 2: 91 percent / 5 h / Heating 3: 1.) Mg / 1.) ether, 2.) ether, 20 deg C, 3 h; reflux, 12 h 4: 80 percent / acetonitrile / 1.) reflux, 3 h, 2.) 20 deg C, 12 h 5: 77 percent / aq. ethanol / 22 h / 20 °C View Scheme

1: 80 percent / acetonitrile / 1.) reflux, 3 h, 2.) 20 deg C, 12 h 2: 77 percent / aq. ethanol / 22 h / 20 °C View Scheme