2-[4-(2-甲基-丙烯基)苯基]丙酸合成路线 （共 11 条）
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 2 h / 35 °C 2: 1.) potassium tert-butoxide, 2.) HCl / 1.) THF, 15 deg C, 2 h; 2.) THF, 15 deg C, 20 min View Scheme
参考文献
Kurtz, Richard R.; Houser, David J.
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 202 - 203
反应条件
sodium hydroxide in ethanol; water
6 h; Ambient temperature;
参考文献
Amano; Yoshikawa; Ogawa; Sano; Ohuchi; Tanami; Ota; Hatayama; Higuchi; Amanuma
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4653 - 4662
反应条件
1: 74 percent / Pd2dba3; AsPh3; LiCl / CuI / 1-methyl-pyrrolidin-2-one / 5 h / 90 °C
2: 85 percent / aq. KOH / ethanol / 4 h / 20 °C
View Scheme
参考文献
Moriconi, Alessio; Cesta, Maria Candida; Cervellera, Maria Neve; Aramini, Andrea; Coniglio, Silvia; Colagioia, Sandro; Beccari, Andrea Rosario; Bizzarri, Cinzia; Cavicchia, Michela Rita; Locati, Massimo; Galliera, Emanuela; Di Benedetto, Paola; Vigilante, Paolo; Bertini, Riccardo; Allegretti, Marcello
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3984 - 4002
反应条件
lithium bromide in N,N-dimethyl-formamide
T=80 - 100°C; 5 h; Yield given;
参考文献
Kurtz, Richard R.; Houser, David J.
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 202 - 203
反应条件
1: 55 percent / NBS, benzoyl peroxide / CCl4 / 6 h / Heating
2: LiBr / dimethylformamide / 5 h / 80 - 100 °C
View Scheme
参考文献
Kurtz, Richard R.; Houser, David J.
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 202 - 203
反应条件
1: 60 percent / acetic anhydride, cc. H2SO4 / 4 h / Heating
2: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF, r.t., 4.5 h
3: 90 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
View Scheme
参考文献
Amano; Yoshikawa; Ogawa; Sano; Ohuchi; Tanami; Ota; Hatayama; Higuchi; Amanuma
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4653 - 4662
反应条件
1: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF, r.t., 4.5 h
2: 90 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
View Scheme
参考文献
Amano; Yoshikawa; Ogawa; Sano; Ohuchi; Tanami; Ota; Hatayama; Higuchi; Amanuma
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4653 - 4662
反应条件
1: 59 percent / tetrahydrofuran / 1 h / 5 - 10 °C
2: 60 percent / acetic anhydride, cc. H2SO4 / 4 h / Heating
3: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF, r.t., 4.5 h
4: 90 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
View Scheme
参考文献
Amano; Yoshikawa; Ogawa; Sano; Ohuchi; Tanami; Ota; Hatayama; Higuchi; Amanuma
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4653 - 4662
反应条件
Yield given. Multistep reaction;
参考文献
Hamon, David P. G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron Letters, 1993 , vol. 34, # 33 p. 5333 - 5336
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=35°C; 2 h;
参考文献
Kurtz, Richard R.; Houser, David J.
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 202 - 203
