hydrogenchloride; trifluoroacetic acid a) 0 deg C, 30 min, b) RT, 30 min;

1: 89 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, overnight 2: 94 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 2 h 3: 60 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, overnight 4: 80 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 20 h 5: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, 20 h 6: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h 7: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min View Scheme

1: 60 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, overnight 2: 80 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 20 h 3: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, 20 h 4: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h 5: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min View Scheme

1: 94 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 2 h 2: 60 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, overnight 3: 80 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 20 h 4: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, 20 h 5: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h 6: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min View Scheme

1: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, 20 h 2: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h 3: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min View Scheme

1: 80 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 20 h 2: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl3 / a) 0 deg C, 1 h, b) RT, 20 h 3: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h 4: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min View Scheme

1: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h 2: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min View Scheme