1-乙炔-2-(1-甲基乙基)苯合成路线 （共 4 条）
反应条件
methanol; potassium carbonate
T=20°C;
参考文献
Tobisu, Mamoru; Nakai, Hiromi; Chatani, Naoto
Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5471 - 5475
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; triphenylphosphine in toluene
T=25°C; Sonogashira coupling; 16.0833 h; Inert atmosphere;
2: With water; potassium hydroxide in methanol; toluene
T=25°C; 3 h; Inert atmosphere;
参考文献
Severin, Rene; Reimer, Jessica; Doye, Sven
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3518 - 3521
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 0 - 20 °C
2: methanol; potassium carbonate / 20 °C
View Scheme
参考文献
Cassar, Doyle J.; Nagaradja, Elisabeth; Butler, David C. D.; Villemin, Didier; Richards, Christopher J.
Organic Letters, 2012 , vol. 14, # 3 p. 894 - 897
反应条件
platinum (II) chloride; copper(I) bromide in toluene
T=120°C; regioselective reaction;
参考文献
Yang, Shangdong; Li, Zigang; Jian, Xing; He, Chuan
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 3999 - 4001
Angewandte Chemie, 2009 , vol. 121, p. 4059 - 4061
