1-(2-氨基-4-苄氧基-5-甲氧基苯基)乙酮合成路线 （共 9 条）
反应条件
1: 2-amino-4-benzyloxy-5-methoxyacetophenone With sodium methylate in ethylene glycol dimethyl ether T=0°C; 1 h; 2: formic acid ethyl ester in ethylene glycol dimethyl ether T=0 - 20°C;
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
Location in patent: Page/Page column 49; 50 ;
WO 2011/045084 A1
反应条件
1.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 1.2: 0 - 20 °C 2.1: trichlorophosphate / 3 h / 110 °C 2.2: Cooling with ice View Scheme
参考文献
WO2011/45084 A1, ;
WO 2011/045084 A1
反应条件
ammonium formate; iron in water; toluene
T=103°C;
参考文献
XI, Dr. Ning
Patent: US2012/219522 A1, 2012 ;
Location in patent: Page/Page column 28 ;
反应条件
sodium hydroxide; ammonium chloride; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate in ethanol; water; acetic acid; N,N-dimethyl-formamide
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1153920 A1, 2001 ;
反应条件
iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6514971 B1, 2003 ;
US 6514971 B1
反应条件
nitric acid; iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Hennequin, Laurent Francois Andre
Patent: US2003/212055 A1, 2003 ;
反应条件
1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux
2: nitric acid; acetic acid / 18 h / 10 - 20 °C
3: zinc; ammonium chloride / ethanol; water / 5 h / Reflux
View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux
2: nitric acid; acetic acid / 18 h / 10 - 20 °C
3: zinc; ammonium chloride / ethanol; water / 5 h / Reflux
View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1: nitric acid; acetic acid / 18 h / 10 - 20 °C
2: zinc; ammonium chloride / ethanol; water / 5 h / Reflux
View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
