6-(甲氧基羰基)-2-萘酸合成路线 （共 23 条）
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: 96 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C
7: 28 percent / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: iPr2NEt; HATU / dimethylformamide / 18 h / 20 °C
6: 100 mg / TBAF / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: iPrNEt; HATU / dimethylformamide / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: 74 percent / Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: 74 percent / Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: Et3N; DMAP / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
