1-[[4-(三氟甲氧基)苯基]磺酰基]哌嗪合成路线 （共 2 条）
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 1 h;
参考文献
VERNALIS (OXFORD) LIMITED; LABORATOIRES SERONO S.A.
Patent: WO2005/19194 A1, 2005 ;
Location in patent: Page/Page column 51-52 ;
WO 2005/019194 A1
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere
2: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; HEER, Jag Paul; CRIDLAND, Andrew Peter; NORTON, David
Patent: WO2011/86377 A1, 2011 ;
WO 2011/086377 A1
