4-溴-3,5-二甲基联苯合成路线 （共 4 条）
反应条件
bromine in tetrachloromethane
T=20°C;
参考文献
Monguchi, Kyoko; Itoh, Tetsuji; Hirai, Katsuyki; Tomioka, Hideo
Journal of the American Chemical Society, 2004 , vol. 126, # 38 p. 11900 - 11913
反应条件
1: With hydrogen bromide; sodium sulfite; copper in water
T=0°C; 2 h; Heating / reflux;
2: With sodium hydroxide in water; toluene
参考文献
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
Patent: EP1602645 A1, 2005 ;
Location in patent: Page/Page column 14 ;
EP 1602645 A1
反应条件
palladium diacetate; sodium carbonate; triphenylphosphine; 3,4,5-trimethoxyphenylboronic acid in water; acetone
18 h; RefluxInert atmosphere;
参考文献
Fujihara, Tetsuaki; Tomike, Yoshikazu; Ohtake, Toshiyuki; Terao, Jun; Tsuji, Yasushi
Chemical Communications, 2011 , vol. 47, # 34 p. 9699 - 9701
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0.42 h / -10 °C / Inert atmosphere
1.2: 2.33 h / -10 - 0 °C / Inert atmosphere
2.1: palladium diacetate; sodium carbonate; triphenylphosphine; 3,4,5-trimethoxyphenylboronic acid / water; acetone / 18 h / Reflux; Inert atmosphere
View Scheme
参考文献
Fujihara, Tetsuaki; Tomike, Yoshikazu; Ohtake, Toshiyuki; Terao, Jun; Tsuji, Yasushi
Chemical Communications, 2011 , vol. 47, # 34 p. 9699 - 9701
