3-氯-4-甲氧基苯乙腈合成路线 （共 18 条）
参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1: HCl
2: propan-2-ol; H2O / Heating
View Scheme
参考文献
Munavalli,S. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3311 - 3318
参考文献
Hromatka
Chemische Berichte, 1942 , vol. 75, p. 123,129
反应条件
1: HCl; benzene / 0 °C
2: ethanol
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参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1.1: AlH3
2.2: 95 percent / BH3 / tetrahydrofuran
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参考文献
Julia,M.; Gaston-Breton,H.
Bulletin de la Societe Chimique de France, 1966 , p. 1335 - 1342
反应条件
1: 18.5 g / BH3 / tetrahydrofuran / 2 h / Heating
2: 32 percent / acetonitrile / 16 h / Heating
3: 65 percent / PPA / 0.5 h / 100 °C
4: 40 percent / BBr3 / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h
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参考文献
Baindur; Tran; Niznik; Guan; Seeman; Neumeyer
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 67 - 72
反应条件
1: aq.-ethanolic KOH-solution
2: potassium hydroxide; sodium hydroxide / 210 °C
3: Erhitzen unter vermindertem Druck
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参考文献
Hromatka
Chemische Berichte, 1942 , vol. 75, p. 123,129
反应条件
1: (i) aq. HBr, (ii) /BRN= 1098229/, HCl
2: (i) NaOEt, (ii) /BRN= 471308/, (iii) aq. NaOH
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参考文献
Kuchar; Brunova; Rejholec; et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 5 p. 1723 - 1735
