2,2,2-三氟-1-对甲苯乙酮肟合成路线 （共 6 条）
反应条件
1: 92 percent / pyridine / 3 h / Heating 2: 91 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 3: 91 percent / Ag2O / diethyl ether / 1 h 4: 58 percent / KMnO4 / pyridine; H2O / 20 h / 50 °C 5: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: pyridine 2: NH3 (liquid) 3: I2; Et3N 4: KMnO4; pyridine View Scheme
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
pyridine 3 h; Heating;
参考文献
Bringmann, Gerhard; Gampe, Christian M.; Reichert, Yanina; Bruhn, Torsten; Faber, Johan H.; Mikyna, Martin; Reichert, Matthias; Leippe, Matthias; Brun, Reto; Gelhaus, Christoph
Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 6104 - 6115
反应条件
1: pyridine
2: NH3 (liquid)
View Scheme
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
1: pyridine
2: NH3 (liquid)
3: I2; Et3N
View Scheme
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
1: pyridine
2: 76 percent / NH3
3: 59 percent / N-bromosuccinimide; AIBN
View Scheme
参考文献
Stromgaard, Kristian; Saito, D. Roland; Shindou, Hideo; Ishii, Satoshi; Shimizu, Takao; Nakanishi, Koji
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4038 - 4046
