2-氯-1-(2-羟基-3-甲基苯基)乙酮合成路线 （共 4 条）
反应条件
1: With AlCl3, aluminium chloride; boron trichloride in dichloromethane
T=0 - 20°C; Friedel Crafts acylation;
2: With hydrogenchloride; water in dichloromethane
2 h; Cooling with ice;
参考文献
Chen, Jie; Shi, Zi-Fa; Zhou, Ling; Xie, An-Le; Cao, Xiao-Ping
Tetrahedron, 2010 , vol. 66, # 19 p. 3499 - 3507
反应条件
aluminium trichloride
T=140°C;
参考文献
v. Auwers
Chemische Berichte, 1916 , vol. 49, p. 815
反应条件
1: 130 °C
2: aluminium chloride / 140 °C
View Scheme
参考文献
v. Auwers
Chemische Berichte, 1916 , vol. 49, p. 815
反应条件
potassium carbonate in acetonitrile
T=20°C; 1 h; Inert atmosphere;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0313; 0499 ;
