1-苄氧基羰基氮杂丁烷-3-羧酸甲酯合成路线 （共 5 条）
反应条件
1: in methanol; hexanes; toluene T=0°C; 2: With acetic acid in methanol; hexanes; toluene
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/78750 A1, 2004 ;
Location in patent: Page 81 ;
WO 2004/078750 A1
反应条件
in diethyl ether T=20°C; 4 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L.
Patent: US2006/229289 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
US2011/183960 A1, ;
Page/Page column 27 ;
反应条件
methanol; sodium hydroxide T=20°C; 3 h;
参考文献
MERCK SHARP and DOHME CORP.; COX, Christopher, D.; BESHORE, Douglas, C.; KIM, June, J.; KUDUK, Scott, D.; MCVEAN, Carol; REGER, Thomas; SHEEN, Justin
Patent: WO2013/52395 A1, 2013 ;
Location in patent: Paragraph 38; 39 ;
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
T=-70 - -20°C; 3 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L.
Patent: US2006/229289 A1, 2006 ;
Location in patent: Page/Page column 19 ;
