4-(4-氨基-3-氟苯氧基)-2-吡啶羧酰胺合成路线 (共 3 条)
反应条件
1: 2-fluoro-4-hydroxyaniline With potassium tert-butylate in dimethyl sulfoxide
T=20°C; 0.25 h;
2: 4-chloro-pyridine-2-carboxylic acid amide in dimethyl sulfoxide
T=80°C; 0.833333 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1889836 A1, 2008 ;
Location in patent: Page/Page column 75 ;
反应条件
potassium tert-butylate in dimethyl sulfoxide
T=20 - 80°C; 1.08333 h; Product distribution / selectivity;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 44 ;
EP 2119706 A1
反应条件
potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide
T=0 - 90°C; 2.5 h; Product distribution / selectivity;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2008/214815 A1, 2008 ;
Location in patent: Page/Page column 19 ;